Buffalo is a city in the U.S. state of New York and the seat of Erie County. Located in Western New York on the eastern shores of Lake Erie and at the head of the Niagara River across from Fort Erie, Ontario, Canada, Buffalo is the principal city of the Buffalo-Niagara Falls metropolitan area, the largest in Upstate New York and 45th largest in the United States. As of the 2010 U.S Census, the city proper had a population of 261,310, making the city the 69th largest city in the United States and the second most populous in the state after New York City. The Buffalo–Niagara–Cattaraugus Combined Statistical Area is home to 1,215,826 residents. Originating around 1789 as a small trading community near the eponymous Buffalo Creek, Buffalo grew quickly after the opening of the Erie Canal in 1825, with the city as its western terminus. By 1900, Buffalo was the 8th largest city in the United States, and went on to become a major railroad hub, and the largest grain-milling center in the country. The latter part of the 20th century saw a reversal of fortunes: Great Lakes shipping was rerouted by the opening of the St. Lawrence Seaway, and steel mills and other heavy industry relocated to places such as China. With the start of Amtrak in the 1970s, Buffalo Central Terminal was also abandoned, and trains were rerouted to nearby Depew, New York (Buffalo-Depew) and Exchange Street Station. By 1990, the city had fallen back below its 1960 population levels. Today, the region’s largest economic sectors are financial services, technology, health care and education, and these continue to grow despite the lagging national and worldwide economies. In recent years, expansions of the Buffalo Niagara Medical Campus and the The State University of New York have led to private and public investment throughout the city and region. A recent study found Buffalo’s April 2014 unemployment rate to be 5.8%. In 2010, Forbes rated Buffalo the 10th best place to raise a family in the United States. Residents of Buffalo are most commonly called “Buffalonians.” Nicknames for the city of Buffalo include “The Queen City”, Buffalo’s most common moniker; “The Nickel City,” due to the appearance of a bison on the back of Indian Head nickel in the early part of the 20th century, “The City of Good Neighbors,” and less commonly, the “City of Light.” Colloquially, Buffalo is often referred to as “(The) B-Lo” by locals.